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In general, the results of weighted analyses showed more intuitive associations. Urinary tract infection in febrile infants younger than eight weeks of age. Large data sets of well-reported primary studies are needed to address this question.

How does study quality affect the results of a diagnostic meta-analysis?

British Journal of Biomedical Science. British Journal of Urology. Although the primary diagnostic literature is extensive, studies are often of low methodological quality or poorly reported.

Support Center Support Center. Acta Paediatrica Scandinavica Supplement.

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Were selection criteria clearly described? An evaluation of Technetiumm dimercaptosuccinic acid DMSA tomographic imaging in children with urinary tract infection. Conclusion Further work is needed to investigate the influence of methodological quality on the results of diagnostic meta-analyses.

These methods may have potential applications in future studies of this type. Where sufficient data were available, we used regression analysis to investigate whether individual QUADAS items and additional variables thought likely to be associated with diagnostic accuracy were associated with the DOR and hence whether differences in these items between the studies accounted for some of the observed heterogeneity.


European Journal Of Nuclear Medicine. Annals Academy of Medicine Singapore. Reporting of the reference standard was poor. We estimated summary receiver operator characteristic SROC curves using the following equation [ 15 ]:. Methods This study was conducted as part of large systematic review of tests used in the diagnosis and further investigation of urinary tract infection UTI in children.

PW and MW participated in data extraction, the analysis of data, and drafted the article. The impact of individual components of QUADAS on a summary measure of diagnostic accuracy was investigated using regression analysis. Although different types of diagnostic tests were evaluated in the three clinical stages used by the review, generalisibility is limited in that all data concerned a single condition UTI. Combined use of urinary alpha1-microglobulin and 99mTc DMSA scintigraphy in the diagnosis and follow-up of acute pyelonephritis and cystitis in children.

Assessing the quality of randomized controlled trials: Assessment of renal function and scarring: American Journal of Diseases of Children.

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Urinary tract infection in young children cannot be excluded with urinalysis. Nitrite screening for urinary tract infection in a Pediatric Emergency Department. The role of excretory urography in the evaluation of girls with urinary tract infection. The use of an appropriate reference standard was also an issue in some of these studies.


The use of an inappropriate spectrum of patients and inadequate reporting of inclusion bacteiroscopico were problematic for studies in this category. Was the reference standard independent of the index test i. Diagnostic value of symptoms and clean-voided urine specimen in childhood urinary tract infection. Bacterioscopicl was the only item investigated to show strong evidence of an association with test performance in the weighted multivariate analysis, although age and geographic region did show moderate evidence of an association in the univariate analysis.

Tests included in the regression analysis number of studies Tests for which there were insufficient studies to permit regression analysis number of studies Diagnosis Dipstick: Pyuria and bacteriuria in urine specimens obtained by catheter from young children with fever.

Was the execution of the reference standard described in sufficient detail to permit its replication? Screening for bacteriuria with Uriglox in children. The localization of urinary tract infection with 99Tc glucoheptonate scintigraphy.